

ABSTRACT

Tertiary butyl esters for use an anticancer drugs have the formula:   &lt;CHEM&gt; wherein R1 and R2 are the same or are different and each is H, Cl, F, Br or I, and R2 may also be NH2; R3, R4 and R5 are the same or are different and each is H, F, Cl, Br or I or C1-C3 alkyl which may be substituted with F, Cl, Br, or I; with the proviso that at least two of R3, R4, and R5 are alkyl or substituted alkyl; and  n is an integer of 0-4. The compounds can be used in treating cancer by significantly increasing the brain levels of the drugs of the invention and their active metabolites.



